Antiphospholipid syndrome and thrombosis

Antiphospholipid Syndrome Presenting with Superior Vena Cava Thrombosis

Thrombosis and the antiphospholipid syndrome.

The antiphospholipid syndrome is an antibody-mediated hypercoagulable state characterized by recurrent venous and arterial thromboembolic events. Several studies have determined that the frequency of antiphospholipid syndrome in patients presenting with a venous thromboembolic event is between 4% and 14%. Because of the high risk for recurrent thromboembolism in these patients, current recommen...

Clinical Management of Antiphospholipid Syndrome-Related Thrombosis

There is evidence that the presence of antiphospholipid antibodies is related with an increased risk of thrombotic events. Patients with definite antiphospholipid syndrome (APS) and a first venous event should receive long term oral anticoagulation to an international normalized ratio (INR) of 2.0-3.0. In patients with definite APS and arterial or recurrent thrombosis oral anticoagulation to an...

Mechanisms of thrombosis in the antiphospholipid syndrome

Los pacientes afectos de síndrome antifosfolipídico (SAF) presentan un riesgo aumentado de padecer trombosis venosas y arteriales, pérdidas fetales recurrentes y/o trombocitopenia. Estas manifestacions clínicas se asocian con la presencia de anticuerpos antifosfolipídicos (AAF), entre los que se incluyen los anticuerpos anticardiolipina (aCL) y el anticoagulante lúpico (AL). A pesar de la estre...

Recurrent brachiocephalic vein thrombosis in antiphospholipid syndrome

We present a case of a middle-aged man with recurrent brachiocephalic vein thrombosis concomitant with antiphospholipid syndrome. The reported case concerns unique involvement of the brachiocephalic vein and the difficulties in laboratory diagnostics of the antiphospholipid syndrome.